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The Karwar Regional Station of CMFRI focuses on several key research areas aimed at the sustainable development of aquaculture and the monitoring of marine resources along the north Karnataka and Goa coast. The research thrust includes the development of sustainable technologies for cage culture of high-value food fishes, broodstock development, breeding, and nursery rearing of important food fishes. Additionally, the station provides consultancy services to the states of Maharashtra, Goa, and Karnataka for open sea cage farming, actively involving local fishermen in the process. The station also works on developing and standardizing health and environmental protocols to support open-sea cage farming initiatives. Over the past five years, the station has achieved significant milestones, including the development of low-cost steel cages for open sea culture of finfish, state-of-the-art nursery rearing technology for Asian seabass and cobia, and innovative methods for the culture of these species in open sea cages. It also contributed to advancements in mooring systems for cage culture and transportation techniques for fish seeds and juveniles over long distances. Furthermore, the station has made notable contributions to understanding disease dynamics in cultured species, reporting the first instances of infections such as Photobactirium damselae subsp damselae in cobia, Vibrio alginolyticus in Asian sea bass, and Vibrio harveyi in red snappers through systematic molecular, biochemical, and histopathological characterization.