 | Dr. H. S. Rao (1947-1950) |
 | Dr. N. K. Panikkar (1950-1957) |
 | Dr. S. Jones (1957-1970) |
 | Dr. R Velappan Nair (Acting Director, 27/02/1970-06/12/1970) |
 | Dr. S. Z. Qasim (1971-1974) |
| Dr. R Velappan Nair (Acting Director, 05/01/1974-24/06/1975) |
 | Dr. E. G. Silas (1975-1985) |
 | Dr. A. V. S. Murthy (Acting Director, 25/06/1985-20/9/1985 ) |
 | Dr. P. S. B. R. James (1985-1994) |
| Dr. P. Vedavyasa Rao (Acting Director, 11/03/1994 - 07/03/1995) |
 | Dr. M. Devaraj (1995-1999) |
 | Dr. V. N. Pillai (1999-2000) |
 | Dr. (Prof.) Mohan Joseph Modayil (2000-2007) |
 | Dr. N Gopalakrishna Pillai (Acting Director, 07/12/2007-07/07/2008) |
 | Dr. Syda Rao (2008-2013) |
 | Dr. A. Gopalakrishnan (2013-2024) |
